People & Culture · Executive Partnership

I learned the business
beside the people running it.

People & Culture Leader · Organizational Design · C-Suite & Board Partner

Fifteen years working with founders, CEOs, and boards. Then every part of the people function, end to end. I see the people function as one connected system, built in partnership with the leaders who run the business.

Catherine Vesey
15+
Years partnering with founders, CEOs & boards
Every
HR function, owned end to end
M&A
Reverse merger, integration & restructuring
Local
Relocating to Charleston, SC

My Approach

One connected
system.

I’m a strategist by nature. The operational precision I taught myself, because the work asked for it — and owning every piece of the function is how I came to see how the pieces fit. I’ve always worked it as one system, side by side with the leaders who run the business.

◉

Alongside the C-suite

Board prep and correspondence. IPO Test-the-Waters roadshows. Investor relations. Enterprise software rolled out company-wide. Midway through at Cerulean, a move into Clinical Operations to restructure the CMO’s office.

◈

Strategy into structure

A board mandate to make a pre-commercial biotech commercial-ready became a people function — policies, systems, performance cycles, culture — built by two people. A 7-day production goal became a new org structure, new shifts, and a payroll framework built from scratch. Four HR platforms became one, on a system we already owned.

◇

In the hard moments

In the room for six staggered workforce reductions — coaching executives beforehand, building every separation package, and delivering the news alongside the CEO. Months after my first tenure at Cartesian ended, an SEC-reportable payroll error surfaced. The CEO asked me to return and bring the company back to full compliance.

Perspective

What I believe about
the future of people work.

The core of HR hasn't gone anywhere — talent, rewards, organizational design, performance. What's changed is everything piled on top of it: AI, new ways of working, burnout, constant restructuring. I think the answer is less about new tools and more about what we choose to protect.

01

Wellness is infrastructure.

It isn't a perk layered on top of the work. It's part of what the organization runs on, and it should be designed, funded, and protected that way — the same as any system a company can't operate without.

02

People are developed by people.

Technology can take on more and more of the machinery of HR, and that frees us for what matters most. Growth happens in relationship — with someone who knows you and stays. That’s the part worth protecting as the tools change.

03

The people function belongs where decisions are made.

Culture and strategy move together. The people function does its best work in the conversation with the CEO and the board from the start, shaping decisions alongside the business.

Experience

Where I've operated,
built, and delivered.

Feb 2025 — Oct 2025

Director, Head of HR Operations

Cartesian Therapeutics · Remote

After my first tenure ended, Cartesian experienced a reportable payroll error and a SEC/SOX compliance issue. The CEO asked me to return and restore payroll and HRIS compliance. I restored People Operations to full compliance and operational excellence, led the full manufacturing operations restructuring to enable 7-day production — redesigning the team structure, running end-to-end recruitment for new manufacturing shifts, and building the shift work framework in both HRIS and payroll from the ground up. Rebuilt the HRIS to full SEC/SOX compliance standards across 60+ employee records, and reduced benefits renewal cost growth from a projected 13%+ down to 3% through broker negotiations and market analysis. Led the annual compensation cycle with AON Radford and re-launched the unlimited PTO policy with clear approval and reporting standards.

Manufacturing HRPayroll ComplianceSEC/SOX RemediationBenefits NegotiationCompensation (AON Radford)HCM / LMSMulti-State Compliance

Nov 2023 — July 2024

Assistant Director, Head of HR Operations

Cartesian Therapeutics · Remote

Continued as the sole HR operator following Selecta's acquisition and transition to Cartesian Therapeutics. Owned all HR operations including payroll administration, benefits open enrollment and renewals, 401(k) plan administration (Fidelity), FMLA management, policy development, and employee communications. Ran talent acquisition from job posting through offer, background checks, I-9 verification, and E-Verify — ensuring full onboarding compliance for every new hire. Supervised a TA contractor and served as the primary point of contact for candidates and hiring managers throughout the full recruitment cycle. Authored the company's Flexible Vacation Policy, T&E Policy, Parental Leave Policy, and time-tracking rollout. Built and pitched the business case to centralize HR operations into a unified HCM platform using existing iSolved infrastructure — a cost-saving solution that avoided purchasing new software.

PayrollFull-Cycle RecruitingI-9 / E-Verify / BGC401(k) AdministrationBenefits & Open EnrollmentFMLAPolicy AuthoringHCM Strategy

Apr 2021 — July 2024

Manager, People and Culture → Assistant Director, HR Operations

Selecta Biosciences · Watertown, MA

Held concurrently with a separate Executive Administration & Operations role for one year (2021–2022) during the formal transition into HR leadership.

Joined as part of a small HR team and grew into the operational core of the function, supporting the Chief People Officer across the full employee lifecycle — from sourcing and recruiting through offer, background checks, I-9 and E-Verify compliance, and onboarding, all the way through offboarding and separation. Ran talent acquisition end-to-end, coordinating with hiring managers, managing candidate pipelines in iSolved ATS, and ensuring every new hire arrived fully compliant and prepared. Co-led the company's Culture Ambassador program and the all-company annual kick-off meeting. Across six staggered workforce reductions, coached executives ahead of each phase, built all separation packages, engaged outplacement services, organized a Lunch & Learn for departing employees covering job searching and resume writing, and coordinated 16 exit discussions on a single day. Built and managed the co-op program, including cross-functional shadowing, cohort interviews, and hiring manager roadmaps.

Full-Cycle RecruitingOnboarding & ComplianceI-9 / E-VerifyBackground ChecksTotal RewardsBenefits AdministrationRIF & SeparationsCulture Programs

2005 — 2021

Executive Operations & C-Suite Partnership

Selecta Biosciences · Cerulean Pharma · Public Preparatory Network · and others

Before transitioning formally into HR, I spent over a decade as a C-Suite executive assistant and operational partner at venture-backed biotech companies and mission-driven nonprofits — supporting CEOs, CMOs, CFOs, and boards at organizations including Selecta Biosciences and Cerulean Pharma.

I coordinated IPO Test-the-Waters roadshows and investor meetings. I managed board communications, drafted board correspondence, and built a perpetual board prep calendar that raised director satisfaction by 85%. I ran investor relations — maintaining the CRM database, preparing backgrounders, and organizing Investor Cocktail Receptions during ASCO. I project managed three company website redesigns and owned the IR webpage. I implemented enterprise software company-wide — sourcing vendors, running RFPs, and training the full organization on adoption. Mid-tenure at Cerulean, I stepped into a Clinical Operations Associate role to restructure the CMO's office.

CEO & CMO SupportBoard ManagementInvestor RelationsIPO RoadshowsExecutive CommunicationsProject ManagementEnterprise Software RolloutOperations

Work Samples

A closer look
at the work.

Some of this I conceived and built myself. Much of it I did in partnership — coaching leaders, facilitating across teams, and bringing the right people into the room at the right time. Partnering has run through my whole career — grant-funded programs, nonprofit fundraising, and C-suite support across investor relations, business development, and clinical operations. Kristen Baldwin, our Chief People Officer at Selecta and my mentor, showed me how to carry that into HR: how to partner with business leaders from within the people function. Samples available upon request.

Partnership · Workforce Reduction

Leading people through a workforce reduction

Selecta’s reduction was staggered across six phases, and each one was planned in layers. We met with the executives first and coached them on leading the conversations, then worked through the logistics together. I built every separation package and arranged outplacement, resume, and job-search support for the people affected. On the day, I was in the room as the HR delegate — delivering the news to each group alongside the CEO and that group’s executive leader. Afterward, I kept communication steady for the people who stayed.

Six staggered reductions, each with executive coaching, separation packages, and transition support in place before the first conversation. The people who left were treated with dignity. The people who stayed had clarity.

Partnership · Change Leadership

Bringing a new leadership team into a public company

After the reverse merger, Cartesian’s legacy leaders came from a private company with no HR function, compensation or promotion process, or public-company compliance experience. Rather than importing systems wholesale, I started with the people — mentoring leaders through the cultural and structural change first, then adapting Selecta’s talent, performance, and culture frameworks to the new organization’s own fundamentals.

Formal HR systems and compliance standards introduced after leaders had been brought along — built around the new culture rather than imposed on it.

Compliance · Payroll · Benefits

Restoring compliance after an SEC-reportable error

Asked to return to Cartesian to restore People Operations after a high-stakes compliance failure that occurred following my first tenure. Remediated an SEC-reportable payroll violation and rebuilt the HRIS to full SEC/SOX compliance standards — correcting data accuracy across 60+ employee records. Simultaneously renegotiated the benefits renewal, reducing projected cost growth from 13%+ down to 3% through broker negotiations and market analysis.

SEC-reportable violation remediated. HRIS rebuilt to SOX compliance. Benefits cost growth cut by 10 percentage points — protecting significant projected spend for plan year 2026.

Manufacturing HR · Workforce Restructuring

Redesigning an organization to scale production

When Cartesian needed to expand to 7-day manufacturing production, I led the full HR side of that buildout — redesigning the team structure and org chart in partnership with Manufacturing leadership, running end-to-end recruitment to hire the additional staff needed for new shifts, and building the shift work framework from scratch in both the HRIS and payroll systems to ensure accurate scheduling, compliance, and compensation processing across all shifts. Delivered expanded capacity without disrupting existing operations or team continuity.

New shift structure operational with compliant HRIS and payroll setup — all hiring, onboarding, and compensation frameworks delivered without production disruption.

Systems Strategy · Cost Management

Using what we already had

Identified that employees were navigating four separate HR platforms, creating friction and administrative burden. Rather than proposing new software, I recognized that iSolved — the system already in place — could be expanded to cover the full employee lifecycle at lower per-user cost than the fragmented status quo. I built the business case from scratch, ran the cost comparison, presented it to leadership, and managed the vendor relationship with iSolved that made expansion possible.

Proposed consolidating from $7/user/mo (fragmented tools) to $6/user/mo (unified HCM), saving money while improving employee experience — by using what we already had, creatively.

Culture · Performance · Employee Experience

Culture & Performance Programs

Co-ran the Culture Ambassador program across four workstreams at Selecta — including launching the company's first annual Pioneer of the Year recognition award at the all-company kick-off meeting. At Cartesian, designed and delivered the company-wide performance management rollout, introducing a quarterly check-in cycle through Small Improvements and coaching managers through the process. Also authored the company's integration communications newsletter (INFORM) during the post-acquisition period, coordinating equity sessions, 401(k) onboarding, and IT office hours.

Performance management launched Feb 2024 across the full organization; culture ambassador program ran for the full 2022–2023 calendar year with structured roadmaps and four active workstreams.

Policy Design · Compliance

Writing the policies people actually live by

Wrote the policies that governed how Cartesian's employees worked — not revised templates from counsel, but substantive, employee-facing documents I authored and owned. Included: the Flexible Vacation Policy (with manager and employee guidance, blackout period rules, and abuse frameworks), the Parental Leave Policy and Manager Guide, the Travel & Expense Policy Guidebook, the Tuition Reimbursement Program, and the Time Reporting and iSolved implementation policy for multi-state and NIH grant compliance.

Policies ranged from operationally complex (multi-state sick time compliance, NIH grant time tracking) to culture-forward (flexible vacation with no accrual cap, parental leave at 100% wages for 12 weeks).

Employer Brand · Creative Direction

Employee Spotlight & Brand Rehaul

Conceptualized and produced an employee spotlight video series in partnership with the external creative firm I hired to lead Selecta's brand and website rehaul. I identified the need, sourced and selected the vendor, directed the creative brief, and shepherded the project from concept through final production — giving the organization a visual identity and narrative that could attract talent and reflect the culture we were building.

One of several deliverables from a full brand and website refresh I led. The spotlight series brought employee voices to the forefront as a recruitment and culture tool.

Leave Management · Compliance

FMLA & Parental Leave Administration

Managed FMLA administration from initial request through return-to-work certification, including coordinating concurrent STD and parental leave, tracking eligibility, requiring medical documentation, and advising managers throughout the process. Authored Cartesian's complete Parental Leave Policy and Manager Guide — covering paid leave entitlements, FMLA interplay, pay and benefits continuity, and a six-step framework for managers on handling parental leave with empathy and compliance.

Policy and manager guide completed April 2025; covers 12 weeks paid parental leave at 100% wages, FMLA eligibility, documentation process, and manager preparation steps from planning through return.

Total Rewards · Benefits & 401(k)

Benefits Administration & 401(k) Oversight

Owned benefits open enrollment and renewals end-to-end — coordinating with brokers and carriers, communicating options to employees, and managing all enrollment data. Served as the 401(k) Plan Administrator for the company's Fidelity retirement plan, which included executing plan document amendments, managing the ADP-to-Fidelity transition, conducting employee information sessions on plan mechanics and account setup, and ensuring DOL compliance.

Coordinated 401(k) information sessions for the full employee population post-acquisition, organized equity grant distribution and E*Trade activation, and executed plan document amendments with Fidelity directly.

In Their Words

From the people who
have seen me work.

"

Catherine was my right hand in all aspects of HR. She held broad responsibilities, including recruitment, benefits, development and culture initiatives, diversity and inclusivity, and HR data and information technology. She possesses an exceptionally high capacity and brings integrity to her work.

Kristen BaldwinChief People Officer, Selecta Biosciences · Direct Manager
"

She ran the day-to-day operations of HR completely independently. Catherine has a good working knowledge of all of the key functional areas of HR and knows how to leverage the resources she has to get things done. She is very diligent, tech savvy and thoughtful — a great mix of all the things you want in an HR professional.

Jessica Wagner Keliher, SPHRChief Human Resources Officer, Cartesian Therapeutics · Direct Manager
"

Catherine is one of the best I have ever seen at figuring out how to get things done efficiently and at speed. I would recommend her to anyone looking to hire her in just about any field, regardless of whether she has prior experience.

Matthew BartholomaeGeneral Counsel & Secretary, Cartesian Therapeutics
"

She is positive and motivated with a get-it-done attitude, but moreover brings a level of strategic partnership to ensure that her business partners are always ahead of the game, whether they be C-level executives, HR leaders, or otherwise.

Brad DahmsChief Financial Officer, Jade Biosciences · Direct Manager

Capabilities

What I bring
to the table.

Enterprise & Executive

  • Board & C-Suite Partnership
  • Organizational Design
  • M&A Integration & Commercial Readiness
  • Workforce Restructuring & RIFs
  • Compensation Strategy (AON Radford)
  • Benefits Strategy & Negotiation
  • Board & Investor Communications

Culture & People Development

  • Culture Building & Recognition
  • Performance Management
  • Learning & Development
  • Employee & Change Communications
  • Employer Brand
  • DEI Initiatives

Operational Foundations

  • Payroll & SEC/SOX Compliance
  • Benefits & 401(k) Administration
  • Leave Management (FMLA)
  • Full-Cycle Talent Acquisition
  • HRIS & ATS (iSolved)
  • Multi-State Compliance
  • Policy Authoring & Rollout

Beyond Work

A life of gratitude.

Italy keeps pulling me back — specifically the parts that are hard to get to, where the effort of getting there makes everything that follows feel more real. Climbing there, not knowing what's at the top or if I'll even make it, has become a physical embodiment of my faith — a daily walk that asks me to keep climbing especially when I can't see the peak, and the overwhelming rush of emotions when met with all the beauty along the way that cannot even be imagined.

"I press on toward the goal for the prize of the upward call of God in Christ Jesus." — Philippians 3:14

Cala Goloritzé · Sardinia  ·  Marettimo · Sicily  ·  Rome  ·  photography

Hiking the cliffs above Marettimo at dawn, Sicily Appian Way · Rome
Biking the Appian Way, Rome Marettimo, Sicily — dawn hike
Caravaggio's Judith Beheading Holofernes, Rome Rock arch trail · Sardinia
Cala Goloritzé, Sardinia Sea cave · Marettimo
Rock arch hiking trail, Sardinia Cala Goloritzé · Sardinia

Let's talk about
what you're building.

Whether you’re building a people function that can carry a company through change, or looking for a strategic partner to work directly alongside an executive or founder — I’d love to hear what you’re working on.